Production of Trichoderma harzianum K179 bioagent for maize diseases control: complete laboratory stage bioprocess development
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Mitrović, IvanaVučurović, Damjan
Al-Ani, Laith Khalil Tawfeeq
Mitrović, Bojan
Bajić, Bojana
Dodić, Siniša
Tančić-Živanov, Sonja
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In order to be competitive on the market, the production of biopreparations needs to be optimized, modelled, and assessed in the early stages of its development. The aim of this paper was to optimize medium for the production of Trichoderma harzianum K179 biocontrol agent, to analyze its kinetics at enlarged laboratory scale and finally economic analysis of the production of this high-value product through simulation modelling. The results showed that the bioprocess of T. harzianum K179 bioagent production in a laboratory bioreactor on the medium with optimal composition (dextrose 10 g l−1, soy flour 6.87 g l−1, K2HPO4 1.51 g l−1, KCl 0.5 g l−1, and MgSO4 × 7H2O 0.5 g l−1), at stirring speed of 1.75 × g and aeration intensity of 1.5 vvm, can be shortened from 96 to 36 h. The results of bioprocess economic analysis showed that with a 25-year project lifetime and an investment payback time of 7.58 years, this project represents an economically viable system.
Keywords:
biocontrol / bioprocessing / optimization / bioproducts / modelling / Trichoderma harzianum / maize / disease controlSource:
Journal of Applied Microbiology, 2023, 134, 6, lxad115-Publisher:
- Oxford : Oxford University Press
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200134 (University of Novi Sad, Faculty of Technology) (RS-MESTD-inst-2020-200134)
- APV 142-451-3213/2020-03 financed by the Provincial Secretariat for Higher Education and Scientific Research, AP Vojvodina
Note:
- The accepted manuscript is available under publisher embargo in this repository at: http://fiver.ifvcns.rs/handle/123456789/4532
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FiVeRTY - JOUR AU - Mitrović, Ivana AU - Vučurović, Damjan AU - Al-Ani, Laith Khalil Tawfeeq AU - Mitrović, Bojan AU - Bajić, Bojana AU - Dodić, Siniša AU - Tančić-Živanov, Sonja PY - 2023 UR - http://fiver.ifvcns.rs/handle/123456789/3979 AB - In order to be competitive on the market, the production of biopreparations needs to be optimized, modelled, and assessed in the early stages of its development. The aim of this paper was to optimize medium for the production of Trichoderma harzianum K179 biocontrol agent, to analyze its kinetics at enlarged laboratory scale and finally economic analysis of the production of this high-value product through simulation modelling. The results showed that the bioprocess of T. harzianum K179 bioagent production in a laboratory bioreactor on the medium with optimal composition (dextrose 10 g l−1, soy flour 6.87 g l−1, K2HPO4 1.51 g l−1, KCl 0.5 g l−1, and MgSO4 × 7H2O 0.5 g l−1), at stirring speed of 1.75 × g and aeration intensity of 1.5 vvm, can be shortened from 96 to 36 h. The results of bioprocess economic analysis showed that with a 25-year project lifetime and an investment payback time of 7.58 years, this project represents an economically viable system. PB - Oxford : Oxford University Press T2 - Journal of Applied Microbiology T1 - Production of Trichoderma harzianum K179 bioagent for maize diseases control: complete laboratory stage bioprocess development IS - 6 SP - lxad115 VL - 134 DO - 10.1093/jambio/lxad115 ER -
@article{ author = "Mitrović, Ivana and Vučurović, Damjan and Al-Ani, Laith Khalil Tawfeeq and Mitrović, Bojan and Bajić, Bojana and Dodić, Siniša and Tančić-Živanov, Sonja", year = "2023", abstract = "In order to be competitive on the market, the production of biopreparations needs to be optimized, modelled, and assessed in the early stages of its development. The aim of this paper was to optimize medium for the production of Trichoderma harzianum K179 biocontrol agent, to analyze its kinetics at enlarged laboratory scale and finally economic analysis of the production of this high-value product through simulation modelling. The results showed that the bioprocess of T. harzianum K179 bioagent production in a laboratory bioreactor on the medium with optimal composition (dextrose 10 g l−1, soy flour 6.87 g l−1, K2HPO4 1.51 g l−1, KCl 0.5 g l−1, and MgSO4 × 7H2O 0.5 g l−1), at stirring speed of 1.75 × g and aeration intensity of 1.5 vvm, can be shortened from 96 to 36 h. The results of bioprocess economic analysis showed that with a 25-year project lifetime and an investment payback time of 7.58 years, this project represents an economically viable system.", publisher = "Oxford : Oxford University Press", journal = "Journal of Applied Microbiology", title = "Production of Trichoderma harzianum K179 bioagent for maize diseases control: complete laboratory stage bioprocess development", number = "6", pages = "lxad115", volume = "134", doi = "10.1093/jambio/lxad115" }
Mitrović, I., Vučurović, D., Al-Ani, L. K. T., Mitrović, B., Bajić, B., Dodić, S.,& Tančić-Živanov, S.. (2023). Production of Trichoderma harzianum K179 bioagent for maize diseases control: complete laboratory stage bioprocess development. in Journal of Applied Microbiology Oxford : Oxford University Press., 134(6), lxad115. https://doi.org/10.1093/jambio/lxad115
Mitrović I, Vučurović D, Al-Ani LKT, Mitrović B, Bajić B, Dodić S, Tančić-Živanov S. Production of Trichoderma harzianum K179 bioagent for maize diseases control: complete laboratory stage bioprocess development. in Journal of Applied Microbiology. 2023;134(6):lxad115. doi:10.1093/jambio/lxad115 .
Mitrović, Ivana, Vučurović, Damjan, Al-Ani, Laith Khalil Tawfeeq, Mitrović, Bojan, Bajić, Bojana, Dodić, Siniša, Tančić-Živanov, Sonja, "Production of Trichoderma harzianum K179 bioagent for maize diseases control: complete laboratory stage bioprocess development" in Journal of Applied Microbiology, 134, no. 6 (2023):lxad115, https://doi.org/10.1093/jambio/lxad115 . .