Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling
Authors
Drinić, ZoricaVladić, Jelena
Vidovic, Senka
Koren, Anamarija
Kiprovski, Biljana
Stojanov, Nadežda
Zeremski, Tijana
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Cannabis sativa L. contains more than 480 known compounds from 18 different chemical
classes. The most important biologically active compounds of industrial hemp are
cannabinoids: Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN),
cannabigerol (CBG), cannabichromene (CBC), and cannabinodiol (CBND). Besides this,
cannabis also contains hydrocarbons, nitrogen-containing compounds, carbohydrates,
flavonoids, noncannabinoid phenols, simple alcohols, aldehydes, ketones, acids, esters, and
lactones.
The extraction of CBD and THC of industrial hemp was carried out by a ultrasound-assisted
technique, an emerging environmentally-friendly technology. The effects of different
extraction parameters (extraction temperature (40-80⁰C), extraction time (20-60 min), and
ultrasonic power (24-60 W/L) on the extraction of CBD and THC were investigated using a
response surface methodology. In obtained extracts content of CBD was in the range from
0.6158 to 0.8752 mg/mL, and con...tent of THC was in the range from 0.0412 to 0.0458
mg/mL. Experimental results were described by the second order polynomial model. Model
was estimated using analysis of variance (ANOVA). The optimization process carried out in
order to obtain the most optimal content of desired types of cannabinoids.
Keywords:
phytocannabinoids / cannabinoids / hemp / Cannabis sativa / ultrasound-assisted extractionSource:
Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia, 2019, 198-198Publisher:
- Novi Sad: University of Novi Sad, Faculty of Technology
Funding / projects:
- APV 114-451-2178/2016-03: Renesansa industrijske konoplje u svetlu aktuelnih agronomsko-medicinskih izazova, financed by the Provincial Secretariat for Higher Education and Scientific Research, AP Vojvodina
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Institution/Community
FiVeRTY - CONF AU - Drinić, Zorica AU - Vladić, Jelena AU - Vidovic, Senka AU - Koren, Anamarija AU - Kiprovski, Biljana AU - Stojanov, Nadežda AU - Zeremski, Tijana PY - 2019 UR - http://fiver.ifvcns.rs/handle/123456789/2224 AB - Cannabis sativa L. contains more than 480 known compounds from 18 different chemical classes. The most important biologically active compounds of industrial hemp are cannabinoids: Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), and cannabinodiol (CBND). Besides this, cannabis also contains hydrocarbons, nitrogen-containing compounds, carbohydrates, flavonoids, noncannabinoid phenols, simple alcohols, aldehydes, ketones, acids, esters, and lactones. The extraction of CBD and THC of industrial hemp was carried out by a ultrasound-assisted technique, an emerging environmentally-friendly technology. The effects of different extraction parameters (extraction temperature (40-80⁰C), extraction time (20-60 min), and ultrasonic power (24-60 W/L) on the extraction of CBD and THC were investigated using a response surface methodology. In obtained extracts content of CBD was in the range from 0.6158 to 0.8752 mg/mL, and content of THC was in the range from 0.0412 to 0.0458 mg/mL. Experimental results were described by the second order polynomial model. Model was estimated using analysis of variance (ANOVA). The optimization process carried out in order to obtain the most optimal content of desired types of cannabinoids. PB - Novi Sad: University of Novi Sad, Faculty of Technology C3 - Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia T1 - Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling EP - 198 SP - 198 UR - https://hdl.handle.net/21.15107/rcub_fiver_2224 ER -
@conference{ author = "Drinić, Zorica and Vladić, Jelena and Vidovic, Senka and Koren, Anamarija and Kiprovski, Biljana and Stojanov, Nadežda and Zeremski, Tijana", year = "2019", abstract = "Cannabis sativa L. contains more than 480 known compounds from 18 different chemical classes. The most important biologically active compounds of industrial hemp are cannabinoids: Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), and cannabinodiol (CBND). Besides this, cannabis also contains hydrocarbons, nitrogen-containing compounds, carbohydrates, flavonoids, noncannabinoid phenols, simple alcohols, aldehydes, ketones, acids, esters, and lactones. The extraction of CBD and THC of industrial hemp was carried out by a ultrasound-assisted technique, an emerging environmentally-friendly technology. The effects of different extraction parameters (extraction temperature (40-80⁰C), extraction time (20-60 min), and ultrasonic power (24-60 W/L) on the extraction of CBD and THC were investigated using a response surface methodology. In obtained extracts content of CBD was in the range from 0.6158 to 0.8752 mg/mL, and content of THC was in the range from 0.0412 to 0.0458 mg/mL. Experimental results were described by the second order polynomial model. Model was estimated using analysis of variance (ANOVA). The optimization process carried out in order to obtain the most optimal content of desired types of cannabinoids.", publisher = "Novi Sad: University of Novi Sad, Faculty of Technology", journal = "Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia", title = "Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling", pages = "198-198", url = "https://hdl.handle.net/21.15107/rcub_fiver_2224" }
Drinić, Z., Vladić, J., Vidovic, S., Koren, A., Kiprovski, B., Stojanov, N.,& Zeremski, T.. (2019). Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling. in Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia Novi Sad: University of Novi Sad, Faculty of Technology., 198-198. https://hdl.handle.net/21.15107/rcub_fiver_2224
Drinić Z, Vladić J, Vidovic S, Koren A, Kiprovski B, Stojanov N, Zeremski T. Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling. in Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia. 2019;:198-198. https://hdl.handle.net/21.15107/rcub_fiver_2224 .
Drinić, Zorica, Vladić, Jelena, Vidovic, Senka, Koren, Anamarija, Kiprovski, Biljana, Stojanov, Nadežda, Zeremski, Tijana, "Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling" in Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia (2019):198-198, https://hdl.handle.net/21.15107/rcub_fiver_2224 .