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Lipidomics-Assisted GWAS (lGWAS) approach for improving high-temperature stress tolerance of crops

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2022
bitstream_8551.pdf (3.727Mb)
Authors
Pranneshraj, Velumani
Sangha, Manjeet Kaur
Đalović, Ivica
Miladinović, Jegor
Djanaguiraman, Maduraimuthu
Article (Published version)
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Abstract
High-temperature stress (HT) over crop productivity is an important environmental factor demanding more attention as recent global warming trends are alarming and pose a potential threat to crop production. According to the Sixth IPCC report, future years will have longer warm seasons and frequent heat waves. Thus, the need arises to develop HT-tolerant genotypes that can be used to breed high-yielding crops. Several physiological, biochemical, and molecular alterations are orchestrated in providing HT tolerance to a genotype. One mechanism to counter HT is overcoming high-temperature-induced membrane superfluidity and structural disorganizations. Several HT lipidomic studies on different genotypes have indicated the potential involvement of membrane lipid remodelling in providing HT tolerance. Advances in high-throughput analytical techniques such as tandem mass spectrometry have paved the way for large-scale identification and quantification of the enormously diverse lipid molecules ...in a single run. Physiological trait-based breeding has been employed so far to identify and select HT tolerant genotypes but has several disadvantages, such as the genotype-phenotype gap affecting the efficiency of identifying the underlying genetic association. Tolerant genotypes maintain a high photosynthetic rate, stable membranes, and membrane-associated mechanisms. In this context, studying the HT-induced membrane lipid remodelling, resultant of several up-/down-regulations of genes and post-translational modifications, will aid in identifying potential lipid biomarkers for HT tolerance/susceptibility. The identified lipid biomarkers (LIPIDOTYPE) can thus be considered an intermediate phenotype, bridging the gap between genotype–phenotype (genotype–LIPIDOTYPE–phenotype). Recent works integrating metabolomics with quantitative genetic studies such as GWAS (mGWAS) have provided close associations between genotype, metabolites, and stress-tolerant phenotypes. This review has been sculpted to provide a potential workflow that combines MS-based lipidomics and the robust GWAS (lipidomics assisted GWAS-lGWAS) to identify membrane lipid remodelling related genes and associations which can be used to develop HS tolerant genotypes with enhanced membrane thermostability (MTS) and heat stable photosynthesis (HP).

Keywords:
high temperature / tolerance mechanism / membrane lipids / lipidomics / photosynthesis / genotypes / phenotypes / GWAS / breeding
Source:
International Journal of Molecular Sciences, 2022, 23, 9389-
Publisher:
  • Basel : MDPI
Funding / projects:
  • BT/PR36115/NNT/28/ 1814/2021 the Department of Biotechnology, Ministry of Science and Technology, Government of India
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200032 (Institute of Field and Vegetable Crops, Novi Sad) (RS-200032)

DOI: 10.3390/ijms23169389

ISSN: 1422-0067; 1661-6596

WoS: 00084658030000

Scopus: 2-s2.0-85137673988
[ Google Scholar ]
URI
http://fiver.ifvcns.rs/handle/123456789/3080
Collections
  • Radovi istraživača / Researchers' papers
Institution/Community
FiVeR
TY  - JOUR
AU  - Pranneshraj, Velumani
AU  - Sangha, Manjeet Kaur
AU  - Đalović, Ivica
AU  - Miladinović, Jegor
AU  - Djanaguiraman, Maduraimuthu
PY  - 2022
UR  - http://fiver.ifvcns.rs/handle/123456789/3080
AB  - High-temperature stress (HT) over crop productivity is an important environmental factor demanding more attention as recent global warming trends are alarming and pose a potential threat to crop production. According to the Sixth IPCC report, future years will have longer warm seasons and frequent heat waves. Thus, the need arises to develop HT-tolerant genotypes that can be used to breed high-yielding crops. Several physiological, biochemical, and molecular alterations are orchestrated in providing HT tolerance to a genotype. One mechanism to counter HT is overcoming high-temperature-induced membrane superfluidity and structural disorganizations. Several HT lipidomic studies on different genotypes have indicated the potential involvement of membrane lipid remodelling in providing HT tolerance. Advances in high-throughput analytical techniques such as tandem mass spectrometry have paved the way for large-scale identification and quantification of the enormously diverse lipid molecules in a single run. Physiological trait-based breeding has been employed so far to identify and select HT tolerant genotypes but has several disadvantages, such as the genotype-phenotype gap affecting the efficiency of identifying the underlying genetic association. Tolerant genotypes maintain a high photosynthetic rate, stable membranes, and membrane-associated mechanisms. In this context, studying the HT-induced membrane lipid remodelling, resultant of several up-/down-regulations of genes and post-translational modifications, will aid in identifying potential lipid biomarkers for HT tolerance/susceptibility. The identified lipid biomarkers (LIPIDOTYPE) can thus be considered an intermediate phenotype, bridging the gap between genotype–phenotype (genotype–LIPIDOTYPE–phenotype). Recent works integrating metabolomics with quantitative genetic studies such as GWAS (mGWAS) have provided close associations between genotype, metabolites, and stress-tolerant phenotypes. This review has been sculpted to provide a potential workflow that combines MS-based lipidomics and the robust GWAS (lipidomics assisted GWAS-lGWAS) to identify membrane lipid remodelling related genes and associations which can be used to develop HS tolerant genotypes with enhanced membrane thermostability (MTS) and heat stable photosynthesis (HP).
PB  - Basel : MDPI
T2  - International Journal of Molecular Sciences
T1  - Lipidomics-Assisted GWAS (lGWAS) approach for improving high-temperature stress tolerance of crops
SP  - 9389
VL  - 23
DO  - 10.3390/ijms23169389
ER  - 
@article{
author = "Pranneshraj, Velumani and Sangha, Manjeet Kaur and Đalović, Ivica and Miladinović, Jegor and Djanaguiraman, Maduraimuthu",
year = "2022",
abstract = "High-temperature stress (HT) over crop productivity is an important environmental factor demanding more attention as recent global warming trends are alarming and pose a potential threat to crop production. According to the Sixth IPCC report, future years will have longer warm seasons and frequent heat waves. Thus, the need arises to develop HT-tolerant genotypes that can be used to breed high-yielding crops. Several physiological, biochemical, and molecular alterations are orchestrated in providing HT tolerance to a genotype. One mechanism to counter HT is overcoming high-temperature-induced membrane superfluidity and structural disorganizations. Several HT lipidomic studies on different genotypes have indicated the potential involvement of membrane lipid remodelling in providing HT tolerance. Advances in high-throughput analytical techniques such as tandem mass spectrometry have paved the way for large-scale identification and quantification of the enormously diverse lipid molecules in a single run. Physiological trait-based breeding has been employed so far to identify and select HT tolerant genotypes but has several disadvantages, such as the genotype-phenotype gap affecting the efficiency of identifying the underlying genetic association. Tolerant genotypes maintain a high photosynthetic rate, stable membranes, and membrane-associated mechanisms. In this context, studying the HT-induced membrane lipid remodelling, resultant of several up-/down-regulations of genes and post-translational modifications, will aid in identifying potential lipid biomarkers for HT tolerance/susceptibility. The identified lipid biomarkers (LIPIDOTYPE) can thus be considered an intermediate phenotype, bridging the gap between genotype–phenotype (genotype–LIPIDOTYPE–phenotype). Recent works integrating metabolomics with quantitative genetic studies such as GWAS (mGWAS) have provided close associations between genotype, metabolites, and stress-tolerant phenotypes. This review has been sculpted to provide a potential workflow that combines MS-based lipidomics and the robust GWAS (lipidomics assisted GWAS-lGWAS) to identify membrane lipid remodelling related genes and associations which can be used to develop HS tolerant genotypes with enhanced membrane thermostability (MTS) and heat stable photosynthesis (HP).",
publisher = "Basel : MDPI",
journal = "International Journal of Molecular Sciences",
title = "Lipidomics-Assisted GWAS (lGWAS) approach for improving high-temperature stress tolerance of crops",
pages = "9389",
volume = "23",
doi = "10.3390/ijms23169389"
}
Pranneshraj, V., Sangha, M. K., Đalović, I., Miladinović, J.,& Djanaguiraman, M.. (2022). Lipidomics-Assisted GWAS (lGWAS) approach for improving high-temperature stress tolerance of crops. in International Journal of Molecular Sciences
Basel : MDPI., 23, 9389.
https://doi.org/10.3390/ijms23169389
Pranneshraj V, Sangha MK, Đalović I, Miladinović J, Djanaguiraman M. Lipidomics-Assisted GWAS (lGWAS) approach for improving high-temperature stress tolerance of crops. in International Journal of Molecular Sciences. 2022;23:9389.
doi:10.3390/ijms23169389 .
Pranneshraj, Velumani, Sangha, Manjeet Kaur, Đalović, Ivica, Miladinović, Jegor, Djanaguiraman, Maduraimuthu, "Lipidomics-Assisted GWAS (lGWAS) approach for improving high-temperature stress tolerance of crops" in International Journal of Molecular Sciences, 23 (2022):9389,
https://doi.org/10.3390/ijms23169389 . .

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