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Određivanje tropanskih alkaloida u kukuruznom flipsu primenom LC-MS/MS

dc.creatorStojanović, Tijana
dc.creatorVuković, Gorica
dc.creatorPetrović, Aleksandra
dc.creatorKonstantinović, Bojan
dc.creatorPuvača, Nikola
dc.creatorMarinković, Dušan
dc.creatorGvozdenac, Sonja
dc.creatorBursić, Vojislava
dc.date.accessioned2022-06-09T09:26:39Z
dc.date.available2022-06-09T09:26:39Z
dc.date.issued2021
dc.identifier.issn0352-4906
dc.identifier.issn2406-0828
dc.identifier.urihttp://fiver.ifvcns.rs/handle/123456789/2828
dc.description.abstractThe interest in tropane alkaloids (TA) as food contaminants is increasing. A sensitive and selective LC-MS/MS method was applied for the analysis of corn puff samples from the Serbian market. Only atropine was quantified in 22% of the samples. In case of scopolamine, although not quantified, it was detected in 22% of the samples. Whether the acute reference dose (ARfD) could be exceeded was checked on a case-by-case basis for the individual products under assessment. Due to their low body weight and relatively high snack consumption, preschool children were at the highest risk of TA exposure. Assuming that the average consumption is 50 g of corn puffs per day, the sample with the highest concentration of TAs (2.05 µg/kg, 1.58 μg/kg of atropine) could contribute with 32.0% to the ARfD, of which 24.7% owing to atropine. If the same amount of corn puffs is consumed by older age classes, corresponding exposure contributions to the ARfD would progressively decline, down to 8.4% for adult population. The study revealed no health risk from TAs exposure through the consumption of the corn puffs in Serbian population.sr
dc.description.abstractInteresovanje za tropanske alkaloide kao kontaminante hrane je u porastu. Za analizu kukuruznog flipsa sa tržišta Srbije primenjena je osetljiva i selektivna LC-MS/MS metoda. Atropin je kvantifikovan u 22% uzoraka. U slučaju skopolamina, koji nije kvantifikovan, detektovano je u 22% uzoraka. Da li može doći do prekoračenja akutne referentne doze provereno je za svaki pojedinačni proizvod koji je uvršten u procenu. Mala telesna masa i relativno velike konzumirane količine snek-proizvoda ističu predškolsku decu kao grupu u najvećem riziku od izloženosti tropanskim alkaloidima. Pod pretpostavkom o konzumiranju 50 grama kukuruznog flipsa dnevno, uzorak s naj­ većom koncentracijom tropanskih alkaloida (2,05 µg/kg, 1,58 mg/kg atropina) može doprineti sa 32,0% od akutne referentne doze, od čega 24,7% odgovara atropinu. Ukoliko istu količinu kukuruznog flipsa konzumiraju starije uzrasne grupe, doprinos sledstvene izloženosti tropanskim alkaloidima bi progresivno opadao do 8,4% za odraslu populaciju. Studija nije ukazala na zdravstveni rizik usled izloženosti tropanskim alkaloidima putem konzumiranja kukuru­ znog flipsa za populaciju u Srbiji.sr
dc.language.isoensr
dc.publisherNovi Sad : Matica srpskasr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceZbornik Matice srpske za prirodne naukesr
dc.subjectanaliza hranesr
dc.subjectatropinsr
dc.subjectkukuruzsr
dc.subjectprocena rizikasr
dc.subjectskopolaminsr
dc.subjectatropinesr
dc.subjectcornsr
dc.subjectfood analysissr
dc.subjectrisk assessmentsr
dc.subjectscopolaminesr
dc.titleDetermination of tropane alkaloids in corn puffs by the LC-MS/MSsr
dc.titleOdređivanje tropanskih alkaloida u kukuruznom flipsu primenom LC-MS/MSsr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dc.citation.epage80
dc.citation.spage69
dc.citation.volume141
dc.identifier.doi10.2298/ZMSPN2141069S
dc.identifier.fulltexthttp://fiver.ifvcns.rs/bitstream/id/7884/bitstream_7884.pdf
dc.type.versionpublishedVersionsr


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