@article{
author = "Aćimović, Milica and Stanković Jeremić, Jovana and Miljković, Ana and Rat, Milica and Lončar, Biljana",
year = "2023",
abstract = "Ironwort (Sideritis montana L.), mountain germander (Teucrium montanum L.), wall germander (Teucrium chamaedrys L.), and horehound (Marrubium peregrinum L.) are species widely distributed
across Europe and are also found in North Africa and West Asia. Because of their wide distribution
they express significant chemical diversity. For generations, these plants have been used as medical
herbs for treating different aliments. The aim of this paper is to analyze volatile compounds of four
selected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientifically
proven biological activities and potential uses in modern phytotherapy in relation to traditional
medicine. Therefore, in this research, we analyze the volatile compounds from this plants, obtained
in laboratory by a Clevenger-type apparatus, followed by liquid–liquid extraction with hexane as the
solvent. The identification of volatile compounds is conducted by GC-FID and GC-MS. Although
these plants are poor in essential oil, the most abundant class of volatile components are mainly
sesquiterpenes: germacrene D (22.6%) in ironwort, 7-epi-trans-sesquisabinene hydrate (15.8%) in
mountain germander, germacrene D (31.8%) and trans-caryophyllene (19.7%) in wall germander, and
trans-caryophyllene (32.4%) and trans-thujone (25.1%) in horehound. Furthermore, many studies
show that, in addition to the essential oil, these plants contain phenols, flavonoids, diterpenes and
diterpenoids, iridoids and their glycosides, coumarins, terpenes, and sterols, among other active
compounds, which affect biological activities. The other goal of this study is to review the literature
that describes the traditional use of these plants in folk medicine in regions where they grow spontaneously and compare them with scientifically confirmed activities. Therefore, a bibliographic search
is conducted on Science Direct, PubMed, and Google Scholar to gather information related to the
topic and recommend potential applications in modern phytotherapy. In conclusion, we can say that
selected plants could be used as natural agents for promoting health, as a source of raw material
in the food industry, and as supplements, as well as in the pharmaceutical industry for developing
plant-based remedies for prevention and treatment of many diseases, especially cancer.",
publisher = "Basel : MDPI",
journal = "Molecules - Basel",
title = "Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia",
number = "12",
pages = "4611",
volume = "28",
doi = "10.3390/molecules28124611"
}