TY  - JOUR
AU  - Drinić, Zorica
AU  - Vladić, Jelena
AU  - Koren, Anamarija
AU  - Zeremski, Tijana
AU  - Stojanov, Nadežda
AU  - Kiprovski, Biljana
AU  - Vidović, Senka
PY  - 2020
UR  - http://fiver.ifvcns.rs/handle/123456789/2002
AB  - BACKGROUND Cannabis (Cannabis sativa L.) is one of the most controversial plants. So far, its multiple application in industry for the production of fabrics, paper and construction materials is known. Today, there is increasing interest in its application for medical purposes, as opposed to its opiate activity. In addition to well-known cannabinoids, the presence of polyphenolic compounds and their antioxidant and reductive abilities are of great importance. Therefore the extraction of both constituents, polyphenolics and cannabinoids (Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD)), of industrial hemp was carried out using microwave-assisted extraction (MAE). RESULTS The effects of different extraction parameters, namely ethanol concentration (30, 50 and 70% v/v), extraction time (10, 20 and 30 min) and solid/liquid ratio (5, 10 and 15 g mL(-1)), on extraction yield, total phenol content, total flavonoid content, antioxidant activity, reductive capacity, CBD content and THC content were investigated using response surface methodology. For the experimental design, a Box-Behnken design was chosen. In the obtained extracts, the following ranges of targeted compounds were detected: total phenols from 0.8499 to 2.7060 mg gallic acid equivalent mL(-1), total flavonoids from 0.4707 to 1.4246 mg catechin equivalent mL(-1), THC from 0.0339 to 0.0637 mg mL(-1) and CBD from 0.2243 to 1.8415 mg mL(-1). Antioxidant activity ranged from 0.0009 to 0.2079 mL mL(-1), while reductive capacity ranged from 0.0021 to 0.0066 mL mL(-1). CONCLUSION MAE proved to be a simple, efficient, fast and low environmental impact method for obtaining polyphenols and cannabinoids from C. sativa L. Cannabis herb, which presents a by-product of fiber and cannabis product, showed to be a promising source of bioactive compounds.
PB  - Wiley, Hoboken
T2  - Journal of Chemical Technology & Biotechnology
T1  - Microwave-assisted extraction of cannabinoids and antioxidants from Cannabis sativa aerial parts and process modeling
EP  - 839
IS  - 3
SP  - 831
VL  - 95
DO  - 10.1002/jctb.6273
ER  - 

@article{
author = "Drinić, Zorica and Vladić, Jelena and Koren, Anamarija and Zeremski, Tijana and Stojanov, Nadežda and Kiprovski, Biljana and Vidović, Senka",
year = "2020",
abstract = "BACKGROUND Cannabis (Cannabis sativa L.) is one of the most controversial plants. So far, its multiple application in industry for the production of fabrics, paper and construction materials is known. Today, there is increasing interest in its application for medical purposes, as opposed to its opiate activity. In addition to well-known cannabinoids, the presence of polyphenolic compounds and their antioxidant and reductive abilities are of great importance. Therefore the extraction of both constituents, polyphenolics and cannabinoids (Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD)), of industrial hemp was carried out using microwave-assisted extraction (MAE). RESULTS The effects of different extraction parameters, namely ethanol concentration (30, 50 and 70% v/v), extraction time (10, 20 and 30 min) and solid/liquid ratio (5, 10 and 15 g mL(-1)), on extraction yield, total phenol content, total flavonoid content, antioxidant activity, reductive capacity, CBD content and THC content were investigated using response surface methodology. For the experimental design, a Box-Behnken design was chosen. In the obtained extracts, the following ranges of targeted compounds were detected: total phenols from 0.8499 to 2.7060 mg gallic acid equivalent mL(-1), total flavonoids from 0.4707 to 1.4246 mg catechin equivalent mL(-1), THC from 0.0339 to 0.0637 mg mL(-1) and CBD from 0.2243 to 1.8415 mg mL(-1). Antioxidant activity ranged from 0.0009 to 0.2079 mL mL(-1), while reductive capacity ranged from 0.0021 to 0.0066 mL mL(-1). CONCLUSION MAE proved to be a simple, efficient, fast and low environmental impact method for obtaining polyphenols and cannabinoids from C. sativa L. Cannabis herb, which presents a by-product of fiber and cannabis product, showed to be a promising source of bioactive compounds.",
publisher = "Wiley, Hoboken",
journal = "Journal of Chemical Technology & Biotechnology",
title = "Microwave-assisted extraction of cannabinoids and antioxidants from Cannabis sativa aerial parts and process modeling",
pages = "839-831",
number = "3",
volume = "95",
doi = "10.1002/jctb.6273"
}

Drinić, Z., Vladić, J., Koren, A., Zeremski, T., Stojanov, N., Kiprovski, B.,& Vidović, S.. (2020). Microwave-assisted extraction of cannabinoids and antioxidants from Cannabis sativa aerial parts and process modeling. in Journal of Chemical Technology & Biotechnology
Wiley, Hoboken., 95(3), 831-839.
https://doi.org/10.1002/jctb.6273

Drinić Z, Vladić J, Koren A, Zeremski T, Stojanov N, Kiprovski B, Vidović S. Microwave-assisted extraction of cannabinoids and antioxidants from Cannabis sativa aerial parts and process modeling. in Journal of Chemical Technology & Biotechnology. 2020;95(3):831-839.
doi:10.1002/jctb.6273 .

Drinić, Zorica, Vladić, Jelena, Koren, Anamarija, Zeremski, Tijana, Stojanov, Nadežda, Kiprovski, Biljana, Vidović, Senka, "Microwave-assisted extraction of cannabinoids and antioxidants from Cannabis sativa aerial parts and process modeling" in Journal of Chemical Technology & Biotechnology, 95, no. 3 (2020):831-839,
https://doi.org/10.1002/jctb.6273 . .

TY  - JOUR
AU  - Vidović, Senka
AU  - Simić, Siniša
AU  - Gavarić, Aleksandra
AU  - Aćimović, Milica
AU  - Vladić, Jelena
PY  - 2020
UR  - http://fiver.ifvcns.rs/handle/123456789/1964
AB  - In this study, supercritical carbon dioxide was applied for the extraction of Artemisia annua L. Moreover, the impact of different parameters of supercritical extraction on total yield was investigated and the obtained yields were compared to the ones obtained by conventional procedures, hydrodistillation and Soxhlet extraction. Supercritical fluid extraction at 40 °C and different pressures (100, 200, and 300 bar) resulted in extraction yields that were in the 2.23-5.18 % range, while the yields at 60 °C and the same pressures were in the range 2.43-3.35 %. The yields obtained by the Soxhlet extraction and hydrodistillation were 10.28 % and 0.10 %, respectively. Although supercritical fluid extraction is inferior to Soxhlet extraction in terms of the recovery of lipophilic components of A. annua, the Soxhlet extraction is not the method of choice for obtaining sweet wormwood extracts due to its numerous disadvantages that include the use of toxic solvents, extended extraction time, health safety of the product, the need for further processing, the impossibility of adjusting the selectivity and thus the composition of the product.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide
EP  - 36
IS  - 40
SP  - 22
DO  - 10.5937/leksir2040022V
ER  - 

@article{
author = "Vidović, Senka and Simić, Siniša and Gavarić, Aleksandra and Aćimović, Milica and Vladić, Jelena",
year = "2020",
abstract = "In this study, supercritical carbon dioxide was applied for the extraction of Artemisia annua L. Moreover, the impact of different parameters of supercritical extraction on total yield was investigated and the obtained yields were compared to the ones obtained by conventional procedures, hydrodistillation and Soxhlet extraction. Supercritical fluid extraction at 40 °C and different pressures (100, 200, and 300 bar) resulted in extraction yields that were in the 2.23-5.18 % range, while the yields at 60 °C and the same pressures were in the range 2.43-3.35 %. The yields obtained by the Soxhlet extraction and hydrodistillation were 10.28 % and 0.10 %, respectively. Although supercritical fluid extraction is inferior to Soxhlet extraction in terms of the recovery of lipophilic components of A. annua, the Soxhlet extraction is not the method of choice for obtaining sweet wormwood extracts due to its numerous disadvantages that include the use of toxic solvents, extended extraction time, health safety of the product, the need for further processing, the impossibility of adjusting the selectivity and thus the composition of the product.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide",
pages = "36-22",
number = "40",
doi = "10.5937/leksir2040022V"
}

Vidović, S., Simić, S., Gavarić, A., Aćimović, M.,& Vladić, J.. (2020). Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(40), 22-36.
https://doi.org/10.5937/leksir2040022V

Vidović S, Simić S, Gavarić A, Aćimović M, Vladić J. Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide. in Lekovite sirovine. 2020;(40):22-36.
doi:10.5937/leksir2040022V .

Vidović, Senka, Simić, Siniša, Gavarić, Aleksandra, Aćimović, Milica, Vladić, Jelena, "Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide" in Lekovite sirovine, no. 40 (2020):22-36,
https://doi.org/10.5937/leksir2040022V . .

TY  - CONF
AU  - Drinić, Zorica
AU  - Vladić, Jelena
AU  - Vidovic, Senka
AU  - Koren, Anamarija
AU  - Kiprovski, Biljana
PY  - 2019
UR  - http://fiver.ifvcns.rs/handle/123456789/2222
AB  - Hemp (Cannabis sativa L.) is an herbaceous annual dioecious plant recognizable for their characteristic spiky leaves from the Cannabaceae family. Cannabis sativa L. is a plant with more than 480 compounds which can be divided into diverse phytochemical classes such as cannabinoids, terpenoids, flavonoids, noncannabinoid phenols, hydrocarbons, nitrogen-containing compounds, carbohydrates. The most studied class is the cannabinoids, but the presence of other bioactive components, especially polyphenols is signifiifcant.
The extraction of polyphenolic compounds of hemp was carried out by subcritical water. The effects of different extraction temperatures (120⁰C – 220⁰C) on the extraction yield, total phenol content, total flavonoid content, and antioxidant activity, determinate by DPPH method, and
reductive capacity, were investigated. Extraction time was 10 minutes. In obtained extracts content of total phenols was in the range from 1.00 to 2.26 mg GAE/mL extract, the content of total flavonoids was in the range from 0.48 to 0.81 mg CE/mL extract. Antioxidant activity was
from 0.0006 to 0.0017 ml extract/ml reaction mixture, while the reductive capacity was from 0.0014 to 0.0058 ml extract/ml reaction mixture.
PB  - Moscow : Peoples' Friendship University of Russia
C3  - Book of Abstracts, 2nd International Scientific Conference "Pharmaceutical Development" 14.11.2019. Moscow, Russia
T1  - Subcritical water extraction of antioxidants from aerial parts of hemp (Cannabis sativa L.)
SP  - 18
UR  - https://hdl.handle.net/21.15107/rcub_fiver_2222
ER  - 

@conference{
author = "Drinić, Zorica and Vladić, Jelena and Vidovic, Senka and Koren, Anamarija and Kiprovski, Biljana",
year = "2019",
abstract = "Hemp (Cannabis sativa L.) is an herbaceous annual dioecious plant recognizable for their characteristic spiky leaves from the Cannabaceae family. Cannabis sativa L. is a plant with more than 480 compounds which can be divided into diverse phytochemical classes such as cannabinoids, terpenoids, flavonoids, noncannabinoid phenols, hydrocarbons, nitrogen-containing compounds, carbohydrates. The most studied class is the cannabinoids, but the presence of other bioactive components, especially polyphenols is signifiifcant.
The extraction of polyphenolic compounds of hemp was carried out by subcritical water. The effects of different extraction temperatures (120⁰C – 220⁰C) on the extraction yield, total phenol content, total flavonoid content, and antioxidant activity, determinate by DPPH method, and
reductive capacity, were investigated. Extraction time was 10 minutes. In obtained extracts content of total phenols was in the range from 1.00 to 2.26 mg GAE/mL extract, the content of total flavonoids was in the range from 0.48 to 0.81 mg CE/mL extract. Antioxidant activity was
from 0.0006 to 0.0017 ml extract/ml reaction mixture, while the reductive capacity was from 0.0014 to 0.0058 ml extract/ml reaction mixture.",
publisher = "Moscow : Peoples' Friendship University of Russia",
journal = "Book of Abstracts, 2nd International Scientific Conference "Pharmaceutical Development" 14.11.2019. Moscow, Russia",
title = "Subcritical water extraction of antioxidants from aerial parts of hemp (Cannabis sativa L.)",
pages = "18",
url = "https://hdl.handle.net/21.15107/rcub_fiver_2222"
}

Drinić, Z., Vladić, J., Vidovic, S., Koren, A.,& Kiprovski, B.. (2019). Subcritical water extraction of antioxidants from aerial parts of hemp (Cannabis sativa L.). in Book of Abstracts, 2nd International Scientific Conference "Pharmaceutical Development" 14.11.2019. Moscow, Russia
Moscow : Peoples' Friendship University of Russia., 18.
https://hdl.handle.net/21.15107/rcub_fiver_2222

Drinić Z, Vladić J, Vidovic S, Koren A, Kiprovski B. Subcritical water extraction of antioxidants from aerial parts of hemp (Cannabis sativa L.). in Book of Abstracts, 2nd International Scientific Conference "Pharmaceutical Development" 14.11.2019. Moscow, Russia. 2019;:18.
https://hdl.handle.net/21.15107/rcub_fiver_2222 .

Drinić, Zorica, Vladić, Jelena, Vidovic, Senka, Koren, Anamarija, Kiprovski, Biljana, "Subcritical water extraction of antioxidants from aerial parts of hemp (Cannabis sativa L.)" in Book of Abstracts, 2nd International Scientific Conference "Pharmaceutical Development" 14.11.2019. Moscow, Russia (2019):18,
https://hdl.handle.net/21.15107/rcub_fiver_2222 .

TY  - CONF
AU  - Drinić, Zorica
AU  - Vladić, Jelena
AU  - Koren, Anamarija
AU  - Kiprovski, Biljana
AU  - Mišan, Aleksandra
AU  - Vidovic, Senka
PY  - 2019
UR  - http://fiver.ifvcns.rs/handle/123456789/2223
AB  - Hemp (Cannabis sativa L.) is an herbaceous annual dioecious plant recognizable for their
characteristic spiky leaves from the Cannabaceae family. C. sativa L. is a complex plant with
more than 480 compounds which can be divided into diverse phytochemical classes such as
cannabinoids, terpenoids, flavonoids, noncannabinoid phenols, hydrocarbons, nitrogen containing compounds, carbohydrates. The most studied class is the cannabinoids, but C. sativa
is a significant source of polyphenols, also. The effect of different water/ethanol mixtures (30, 50, 70, and 90%) and pure water on the polyphenol content and antioxidant activity of C. sativa L. extracts obtained by classical extraction at room temperature for 24 h was investigated. Two different samples were used, aerial parts of young hemp and aerial parts of mature hemp. Young hemp present stage of plant growth before the plant has a reproductive organ, and a mature plant is one which is an incomplete stage of growth with flowers as reproductive organs. The extraction yield, qualitative and quantitative phenolic profiles, total phenols content, total flavonoids content, antioxidant activity, and reductive capacity were determinate in the obtained extracts. TP was from 5.76 to 17.05 mg GAE/g dw for aerial parts of young hemp, and from 5.00 to 10.48 mg GAE/g dw for aerial parts of mature hemp. TF content was from 2.37 to 4.82 mg CE/g dw and from 1.67 to 3.58 mg CE/g dw for aerial parts of young hemp and aerial parts of mature hemp, respectively. Sinapic acid, protocatechin acid, vanillic acid, syringic acid, epicatechin acid, ferulic acid, isovitexin, rutin, cinnamic acid, naringenin, and apigenin were detected in hemp extracts. Antioxidant activity in obtained extracts was determined by the DPPH assay.
IC50 values were from 0.1600 to 0.6700 mg/mL and from 0.2500 to 1.7900 mg/mL for aerial
parts of young and mature hemp, respectively. Reductive capacity was expressed by EC50
values. EC50 were in the range from 0.5800 to 0.9700 mg/mL for young hemp extracts, while
for mature hemp extracts were from 0.7200 to 1.5800 mg/mL.
PB  - Szeged: University of Szeged
C3  - Book of Abstracts, 25th International Symposium on Analytical and Environmental Problems, 07-08.10.2019, Szeged, Hungary, p.128
T1  - Classical extraction of polyphenolic compounds from industrial hemp (Cannabis sativa L.)
SP  - 128
UR  - https://hdl.handle.net/21.15107/rcub_fiver_2223
ER  - 

@conference{
author = "Drinić, Zorica and Vladić, Jelena and Koren, Anamarija and Kiprovski, Biljana and Mišan, Aleksandra and Vidovic, Senka",
year = "2019",
abstract = "Hemp (Cannabis sativa L.) is an herbaceous annual dioecious plant recognizable for their
characteristic spiky leaves from the Cannabaceae family. C. sativa L. is a complex plant with
more than 480 compounds which can be divided into diverse phytochemical classes such as
cannabinoids, terpenoids, flavonoids, noncannabinoid phenols, hydrocarbons, nitrogen containing compounds, carbohydrates. The most studied class is the cannabinoids, but C. sativa
is a significant source of polyphenols, also. The effect of different water/ethanol mixtures (30, 50, 70, and 90%) and pure water on the polyphenol content and antioxidant activity of C. sativa L. extracts obtained by classical extraction at room temperature for 24 h was investigated. Two different samples were used, aerial parts of young hemp and aerial parts of mature hemp. Young hemp present stage of plant growth before the plant has a reproductive organ, and a mature plant is one which is an incomplete stage of growth with flowers as reproductive organs. The extraction yield, qualitative and quantitative phenolic profiles, total phenols content, total flavonoids content, antioxidant activity, and reductive capacity were determinate in the obtained extracts. TP was from 5.76 to 17.05 mg GAE/g dw for aerial parts of young hemp, and from 5.00 to 10.48 mg GAE/g dw for aerial parts of mature hemp. TF content was from 2.37 to 4.82 mg CE/g dw and from 1.67 to 3.58 mg CE/g dw for aerial parts of young hemp and aerial parts of mature hemp, respectively. Sinapic acid, protocatechin acid, vanillic acid, syringic acid, epicatechin acid, ferulic acid, isovitexin, rutin, cinnamic acid, naringenin, and apigenin were detected in hemp extracts. Antioxidant activity in obtained extracts was determined by the DPPH assay.
IC50 values were from 0.1600 to 0.6700 mg/mL and from 0.2500 to 1.7900 mg/mL for aerial
parts of young and mature hemp, respectively. Reductive capacity was expressed by EC50
values. EC50 were in the range from 0.5800 to 0.9700 mg/mL for young hemp extracts, while
for mature hemp extracts were from 0.7200 to 1.5800 mg/mL.",
publisher = "Szeged: University of Szeged",
journal = "Book of Abstracts, 25th International Symposium on Analytical and Environmental Problems, 07-08.10.2019, Szeged, Hungary, p.128",
title = "Classical extraction of polyphenolic compounds from industrial hemp (Cannabis sativa L.)",
pages = "128",
url = "https://hdl.handle.net/21.15107/rcub_fiver_2223"
}

Drinić, Z., Vladić, J., Koren, A., Kiprovski, B., Mišan, A.,& Vidovic, S.. (2019). Classical extraction of polyphenolic compounds from industrial hemp (Cannabis sativa L.). in Book of Abstracts, 25th International Symposium on Analytical and Environmental Problems, 07-08.10.2019, Szeged, Hungary, p.128
Szeged: University of Szeged., 128.
https://hdl.handle.net/21.15107/rcub_fiver_2223

Drinić Z, Vladić J, Koren A, Kiprovski B, Mišan A, Vidovic S. Classical extraction of polyphenolic compounds from industrial hemp (Cannabis sativa L.). in Book of Abstracts, 25th International Symposium on Analytical and Environmental Problems, 07-08.10.2019, Szeged, Hungary, p.128. 2019;:128.
https://hdl.handle.net/21.15107/rcub_fiver_2223 .

Drinić, Zorica, Vladić, Jelena, Koren, Anamarija, Kiprovski, Biljana, Mišan, Aleksandra, Vidovic, Senka, "Classical extraction of polyphenolic compounds from industrial hemp (Cannabis sativa L.)" in Book of Abstracts, 25th International Symposium on Analytical and Environmental Problems, 07-08.10.2019, Szeged, Hungary, p.128 (2019):128,
https://hdl.handle.net/21.15107/rcub_fiver_2223 .

TY  - CONF
AU  - Drinić, Zorica
AU  - Vladić, Jelena
AU  - Vidovic, Senka
AU  - Koren, Anamarija
AU  - Kiprovski, Biljana
AU  - Stojanov, Nadežda
AU  - Zeremski, Tijana
PY  - 2019
UR  - http://fiver.ifvcns.rs/handle/123456789/2224
AB  - Cannabis sativa L. contains more than 480 known compounds from 18 different chemical
classes. The most important biologically active compounds of industrial hemp are
cannabinoids: Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN),
cannabigerol (CBG), cannabichromene (CBC), and cannabinodiol (CBND). Besides this,
cannabis also contains hydrocarbons, nitrogen-containing compounds, carbohydrates,
flavonoids, noncannabinoid phenols, simple alcohols, aldehydes, ketones, acids, esters, and
lactones.
The extraction of CBD and THC of industrial hemp was carried out by a ultrasound-assisted
technique, an emerging environmentally-friendly technology. The effects of different
extraction parameters (extraction temperature (40-80⁰C), extraction time (20-60 min), and
ultrasonic power (24-60 W/L) on the extraction of CBD and THC were investigated using a
response surface methodology. In obtained extracts content of CBD was in the range from
0.6158 to 0.8752 mg/mL, and content of THC was in the range from 0.0412 to 0.0458
mg/mL. Experimental results were described by the second order polynomial model. Model
was estimated using analysis of variance (ANOVA). The optimization process carried out in
order to obtain the most optimal content of desired types of cannabinoids.
PB  - Novi Sad: University of Novi Sad, Faculty of Technology
C3  - Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia
T1  - Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling
EP  - 198
SP  - 198
UR  - https://hdl.handle.net/21.15107/rcub_fiver_2224
ER  - 

@conference{
author = "Drinić, Zorica and Vladić, Jelena and Vidovic, Senka and Koren, Anamarija and Kiprovski, Biljana and Stojanov, Nadežda and Zeremski, Tijana",
year = "2019",
abstract = "Cannabis sativa L. contains more than 480 known compounds from 18 different chemical
classes. The most important biologically active compounds of industrial hemp are
cannabinoids: Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN),
cannabigerol (CBG), cannabichromene (CBC), and cannabinodiol (CBND). Besides this,
cannabis also contains hydrocarbons, nitrogen-containing compounds, carbohydrates,
flavonoids, noncannabinoid phenols, simple alcohols, aldehydes, ketones, acids, esters, and
lactones.
The extraction of CBD and THC of industrial hemp was carried out by a ultrasound-assisted
technique, an emerging environmentally-friendly technology. The effects of different
extraction parameters (extraction temperature (40-80⁰C), extraction time (20-60 min), and
ultrasonic power (24-60 W/L) on the extraction of CBD and THC were investigated using a
response surface methodology. In obtained extracts content of CBD was in the range from
0.6158 to 0.8752 mg/mL, and content of THC was in the range from 0.0412 to 0.0458
mg/mL. Experimental results were described by the second order polynomial model. Model
was estimated using analysis of variance (ANOVA). The optimization process carried out in
order to obtain the most optimal content of desired types of cannabinoids.",
publisher = "Novi Sad: University of Novi Sad, Faculty of Technology",
journal = "Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia",
title = "Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling",
pages = "198-198",
url = "https://hdl.handle.net/21.15107/rcub_fiver_2224"
}

Drinić, Z., Vladić, J., Vidovic, S., Koren, A., Kiprovski, B., Stojanov, N.,& Zeremski, T.. (2019). Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling. in Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia
Novi Sad: University of Novi Sad, Faculty of Technology., 198-198.
https://hdl.handle.net/21.15107/rcub_fiver_2224

Drinić Z, Vladić J, Vidovic S, Koren A, Kiprovski B, Stojanov N, Zeremski T. Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling. in Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia. 2019;:198-198.
https://hdl.handle.net/21.15107/rcub_fiver_2224 .

Drinić, Zorica, Vladić, Jelena, Vidovic, Senka, Koren, Anamarija, Kiprovski, Biljana, Stojanov, Nadežda, Zeremski, Tijana, "Ultrasound-assisted extraction of cannabidiol and -tetrahydrocannabinol from Cannabis areal parts and process modeling" in Book of Abstracts, ICAPP – The First International Conference on Advanced Production and Processing. 10-11.10.2019. Novi Sad, Serbia (2019):198-198,
https://hdl.handle.net/21.15107/rcub_fiver_2224 .

TY  - JOUR
AU  - Drinić, Zorica
AU  - Vidović, Senka
AU  - Vladić, Jelena
AU  - Koren, Anamarija
AU  - Kiprovski, Biljana
AU  - Sikora, Vladimir
PY  - 2018
UR  - http://fiver.ifvcns.rs/handle/123456789/1789
AB  - In this study, water and various concentrations of ethanol in water (30 %, 50 %, 70 %, and 90 %) were used as a solvent in the extraction of two different samples of hemp (Cannabis sativa L.). The extraction yield, total phenols content, total flavonoids content, antioxidant activity, and reductive capacity were determined in the obtained extracts. The extraction yield was from 8.16 to 19.56 %, the content of total phenols was in the range from 5.85 to 17.05 mg GAE/g dw, and content of total flavonoids was in the range from 5.85 to 9.25 mg CE/g dw. Antioxidant activity was tested by DPPH assay and EC50 values were from 0.1331 to 0.7563 mg/mL, while EC50 values obtained by reducing power test ranged from 0.4450 to 1.1980 mg/mL. Ethanol/water mixture (50 %) was determined to be the best solvent for the extraction of phenolic compounds from both hemp samples. Total phenols content in 50 % ethanolic extracts were 17.05 mg/g dw and 9.25 mg/g dw for young and mature hemp, respectively.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Effect of extraction solvent on total polyphenols content and antioxidant activity of Cannabis sativa L.
EP  - 21
IS  - 38
SP  - 17
DO  - 10.5937/leksir1838017D
ER  - 

@article{
author = "Drinić, Zorica and Vidović, Senka and Vladić, Jelena and Koren, Anamarija and Kiprovski, Biljana and Sikora, Vladimir",
year = "2018",
abstract = "In this study, water and various concentrations of ethanol in water (30 %, 50 %, 70 %, and 90 %) were used as a solvent in the extraction of two different samples of hemp (Cannabis sativa L.). The extraction yield, total phenols content, total flavonoids content, antioxidant activity, and reductive capacity were determined in the obtained extracts. The extraction yield was from 8.16 to 19.56 %, the content of total phenols was in the range from 5.85 to 17.05 mg GAE/g dw, and content of total flavonoids was in the range from 5.85 to 9.25 mg CE/g dw. Antioxidant activity was tested by DPPH assay and EC50 values were from 0.1331 to 0.7563 mg/mL, while EC50 values obtained by reducing power test ranged from 0.4450 to 1.1980 mg/mL. Ethanol/water mixture (50 %) was determined to be the best solvent for the extraction of phenolic compounds from both hemp samples. Total phenols content in 50 % ethanolic extracts were 17.05 mg/g dw and 9.25 mg/g dw for young and mature hemp, respectively.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Effect of extraction solvent on total polyphenols content and antioxidant activity of Cannabis sativa L.",
pages = "21-17",
number = "38",
doi = "10.5937/leksir1838017D"
}

Drinić, Z., Vidović, S., Vladić, J., Koren, A., Kiprovski, B.,& Sikora, V.. (2018). Effect of extraction solvent on total polyphenols content and antioxidant activity of Cannabis sativa L.. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(38), 17-21.
https://doi.org/10.5937/leksir1838017D

Drinić Z, Vidović S, Vladić J, Koren A, Kiprovski B, Sikora V. Effect of extraction solvent on total polyphenols content and antioxidant activity of Cannabis sativa L.. in Lekovite sirovine. 2018;(38):17-21.
doi:10.5937/leksir1838017D .

Drinić, Zorica, Vidović, Senka, Vladić, Jelena, Koren, Anamarija, Kiprovski, Biljana, Sikora, Vladimir, "Effect of extraction solvent on total polyphenols content and antioxidant activity of Cannabis sativa L." in Lekovite sirovine, no. 38 (2018):17-21,
https://doi.org/10.5937/leksir1838017D . .

TY  - CHAP
AU  - Gavarić, Aleksandra
AU  - Jokić, Stela
AU  - Molnar, Maja
AU  - Vidović, Senka
AU  - Vladić, Jelena
AU  - Aćimović, Milica
PY  - 2017
UR  - http://fiver.ifvcns.rs/handle/123456789/2442
AB  - The genus Helichrysum consists of 600 species, among which the most significant are dwarf everlast (Helichrysum arenarium) and curry plant (Helichrysum italicum). The H. arenarium spreads from the Mediterranean to Northern Europe, while H. italicum grows exclusively in the Mediterranean countries. Only H. italicum is cultivated for the production of essential oil. As a perennial plant, H. italicum is cultivated on the same location for 5-8 years. Therefore, a lot of care should be taken when choosing the plot because this plant thrives on sandy and rocky soil with a lot of sunshine. Alkaline soil (with a lot of calcium) that retains water well is the best type of soil for this plant. H. italicum can reproduce generative, by seed through seedlings, and vegetative, by cuttings.
PB  - Nova Science Publishers
T2  - Medicinal plants - production, cultivation and uses
T1  - Helichrysum: the current state of cultivation, production and uses
EP  - 105
SP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_fiver_2442
ER  - 

@inbook{
author = "Gavarić, Aleksandra and Jokić, Stela and Molnar, Maja and Vidović, Senka and Vladić, Jelena and Aćimović, Milica",
year = "2017",
abstract = "The genus Helichrysum consists of 600 species, among which the most significant are dwarf everlast (Helichrysum arenarium) and curry plant (Helichrysum italicum). The H. arenarium spreads from the Mediterranean to Northern Europe, while H. italicum grows exclusively in the Mediterranean countries. Only H. italicum is cultivated for the production of essential oil. As a perennial plant, H. italicum is cultivated on the same location for 5-8 years. Therefore, a lot of care should be taken when choosing the plot because this plant thrives on sandy and rocky soil with a lot of sunshine. Alkaline soil (with a lot of calcium) that retains water well is the best type of soil for this plant. H. italicum can reproduce generative, by seed through seedlings, and vegetative, by cuttings.",
publisher = "Nova Science Publishers",
journal = "Medicinal plants - production, cultivation and uses",
booktitle = "Helichrysum: the current state of cultivation, production and uses",
pages = "105-85",
url = "https://hdl.handle.net/21.15107/rcub_fiver_2442"
}

Gavarić, A., Jokić, S., Molnar, M., Vidović, S., Vladić, J.,& Aćimović, M.. (2017). Helichrysum: the current state of cultivation, production and uses. in Medicinal plants - production, cultivation and uses
Nova Science Publishers., 85-105.
https://hdl.handle.net/21.15107/rcub_fiver_2442

Gavarić A, Jokić S, Molnar M, Vidović S, Vladić J, Aćimović M. Helichrysum: the current state of cultivation, production and uses. in Medicinal plants - production, cultivation and uses. 2017;:85-105.
https://hdl.handle.net/21.15107/rcub_fiver_2442 .

Gavarić, Aleksandra, Jokić, Stela, Molnar, Maja, Vidović, Senka, Vladić, Jelena, Aćimović, Milica, "Helichrysum: the current state of cultivation, production and uses" in Medicinal plants - production, cultivation and uses (2017):85-105,
https://hdl.handle.net/21.15107/rcub_fiver_2442 .

TY  - CHAP
AU  - Vidović, Senka
AU  - Savikin, Katarina
AU  - Aćimović, Milica
AU  - Vladić, Jelena
AU  - Ćujić, Nada
AU  - Gavarić, Aleksandra
AU  - Janković, Teodora
PY  - 2017
UR  - http://fiver.ifvcns.rs/handle/123456789/2441
AB  - Aronia, also called chokeberry, is a member of the Rosaceae family. The genus is usually considered to contain two species: black chokeberry, Aronia melanocarpa (Michx.) Ell., and red chokeberry, Aronia arbutifolia (L.) Pers. (Kokotkiewicz et al., 2010; Kulling and Rawel, 2008). Black. A. melanocarpa (Michx.) Ell. is more prevalent. It is spread across North America, Europe, Russia and Ukraine, where it is a common mass-produced plant. It grows in a form of a shrub 2–3 m tall, and can live up to 20 years. Ripening phase of aronia starts in late July, and harvest is performed between August and September. The first harvest can be done after three years, whereas the full yield of 5-10 kg fruit per shrub or 5-12 t/ha, can be expected in about five years once plants have matured. A series of factors, such as habitat/location, harvest date, cultivar, fertilization, and maturation of the berries can affect the content of aronia phytochemicals.
PB  - Nova Science Publishers
T2  - Medicinal plants - production, cultivation and uses
T1  - Insight to the current state and challenges in Aronia melanocarpa cultivation, phytochemicals, potential and applications
EP  - 84
SP  - 59
UR  - https://hdl.handle.net/21.15107/rcub_fiver_2441
ER  - 

@inbook{
author = "Vidović, Senka and Savikin, Katarina and Aćimović, Milica and Vladić, Jelena and Ćujić, Nada and Gavarić, Aleksandra and Janković, Teodora",
year = "2017",
abstract = "Aronia, also called chokeberry, is a member of the Rosaceae family. The genus is usually considered to contain two species: black chokeberry, Aronia melanocarpa (Michx.) Ell., and red chokeberry, Aronia arbutifolia (L.) Pers. (Kokotkiewicz et al., 2010; Kulling and Rawel, 2008). Black. A. melanocarpa (Michx.) Ell. is more prevalent. It is spread across North America, Europe, Russia and Ukraine, where it is a common mass-produced plant. It grows in a form of a shrub 2–3 m tall, and can live up to 20 years. Ripening phase of aronia starts in late July, and harvest is performed between August and September. The first harvest can be done after three years, whereas the full yield of 5-10 kg fruit per shrub or 5-12 t/ha, can be expected in about five years once plants have matured. A series of factors, such as habitat/location, harvest date, cultivar, fertilization, and maturation of the berries can affect the content of aronia phytochemicals.",
publisher = "Nova Science Publishers",
journal = "Medicinal plants - production, cultivation and uses",
booktitle = "Insight to the current state and challenges in Aronia melanocarpa cultivation, phytochemicals, potential and applications",
pages = "84-59",
url = "https://hdl.handle.net/21.15107/rcub_fiver_2441"
}

Vidović, S., Savikin, K., Aćimović, M., Vladić, J., Ćujić, N., Gavarić, A.,& Janković, T.. (2017). Insight to the current state and challenges in Aronia melanocarpa cultivation, phytochemicals, potential and applications. in Medicinal plants - production, cultivation and uses
Nova Science Publishers., 59-84.
https://hdl.handle.net/21.15107/rcub_fiver_2441

Vidović S, Savikin K, Aćimović M, Vladić J, Ćujić N, Gavarić A, Janković T. Insight to the current state and challenges in Aronia melanocarpa cultivation, phytochemicals, potential and applications. in Medicinal plants - production, cultivation and uses. 2017;:59-84.
https://hdl.handle.net/21.15107/rcub_fiver_2441 .

Vidović, Senka, Savikin, Katarina, Aćimović, Milica, Vladić, Jelena, Ćujić, Nada, Gavarić, Aleksandra, Janković, Teodora, "Insight to the current state and challenges in Aronia melanocarpa cultivation, phytochemicals, potential and applications" in Medicinal plants - production, cultivation and uses (2017):59-84,
https://hdl.handle.net/21.15107/rcub_fiver_2441 .

TY  - CHAP
AU  - Vladić, Jelena
AU  - Vidović, Senka
AU  - Aćimović, Milica
AU  - Gavarić, Aleksandra
AU  - Jokić, Stela
PY  - 2017
UR  - http://fiver.ifvcns.rs/handle/123456789/2440
AB  - The application of medicinal herbs in the prevention and treatment of certain medical conditions is a concept that has become widely present. On the one hand, the reasons for this are poverty and unavailability of synthetic drugs, and on the other, there is a mistrust of synthetic drugs due to their adverse side effects. One herbal species which is quite popular in traditional medicine is Satureja montana L. Its presence in indigenous remedies has served as a basis for numerous scientific researches which determined its significant pharmacological activities, such as: diuretic, antibacterial, antifungal, antiviral, antioxidant, neuroprotective, antiproliferative, and others. Utilization in folk medicine for particular medical conditions and diseases, and its scientific validity, caused a necessity for production of products on the basis of S. montana. However, a difficulty that occurs during the process is the unevenness of chemical composition of S. montana, which grows in nature and is harvested. The huge inconsistency and differences in the content of compounds exist among dominant ones (carvacrol and thymol), as well as those that are present in lower concentrations (p-cymene, linalool, γ-terpinene, etc.). The differences are caused by different stadiums of ontogenetic development, geographical terrain, climatic conditions, time and way of harvesting, availability of water and nutrients, pathogenic attacks, and many other factors. Because of the huge variations of the chemical composition, the activity of the product on the basis of S. montana is directly affected. Therefore, it is necessary to Jelena Vladic, Senka Vidovic, Milica Acimovic et al. provide quality raw material with a uniform composition, that is, to standardize cultivation. Proper cultivation provides a high quality raw material with uniform chemical content which is suitable for use in the production of functional S. montana-based products.
PB  - Nova Science Publishers
T2  - Medicinal plants - production, cultivation and uses
T1  - Satureja montana: cultivation, production and uses
EP  - 57
SP  - 27
UR  - https://hdl.handle.net/21.15107/rcub_fiver_2440
ER  - 

@inbook{
author = "Vladić, Jelena and Vidović, Senka and Aćimović, Milica and Gavarić, Aleksandra and Jokić, Stela",
year = "2017",
abstract = "The application of medicinal herbs in the prevention and treatment of certain medical conditions is a concept that has become widely present. On the one hand, the reasons for this are poverty and unavailability of synthetic drugs, and on the other, there is a mistrust of synthetic drugs due to their adverse side effects. One herbal species which is quite popular in traditional medicine is Satureja montana L. Its presence in indigenous remedies has served as a basis for numerous scientific researches which determined its significant pharmacological activities, such as: diuretic, antibacterial, antifungal, antiviral, antioxidant, neuroprotective, antiproliferative, and others. Utilization in folk medicine for particular medical conditions and diseases, and its scientific validity, caused a necessity for production of products on the basis of S. montana. However, a difficulty that occurs during the process is the unevenness of chemical composition of S. montana, which grows in nature and is harvested. The huge inconsistency and differences in the content of compounds exist among dominant ones (carvacrol and thymol), as well as those that are present in lower concentrations (p-cymene, linalool, γ-terpinene, etc.). The differences are caused by different stadiums of ontogenetic development, geographical terrain, climatic conditions, time and way of harvesting, availability of water and nutrients, pathogenic attacks, and many other factors. Because of the huge variations of the chemical composition, the activity of the product on the basis of S. montana is directly affected. Therefore, it is necessary to Jelena Vladic, Senka Vidovic, Milica Acimovic et al. provide quality raw material with a uniform composition, that is, to standardize cultivation. Proper cultivation provides a high quality raw material with uniform chemical content which is suitable for use in the production of functional S. montana-based products.",
publisher = "Nova Science Publishers",
journal = "Medicinal plants - production, cultivation and uses",
booktitle = "Satureja montana: cultivation, production and uses",
pages = "57-27",
url = "https://hdl.handle.net/21.15107/rcub_fiver_2440"
}

Vladić, J., Vidović, S., Aćimović, M., Gavarić, A.,& Jokić, S.. (2017). Satureja montana: cultivation, production and uses. in Medicinal plants - production, cultivation and uses
Nova Science Publishers., 27-57.
https://hdl.handle.net/21.15107/rcub_fiver_2440

Vladić J, Vidović S, Aćimović M, Gavarić A, Jokić S. Satureja montana: cultivation, production and uses. in Medicinal plants - production, cultivation and uses. 2017;:27-57.
https://hdl.handle.net/21.15107/rcub_fiver_2440 .

Vladić, Jelena, Vidović, Senka, Aćimović, Milica, Gavarić, Aleksandra, Jokić, Stela, "Satureja montana: cultivation, production and uses" in Medicinal plants - production, cultivation and uses (2017):27-57,
https://hdl.handle.net/21.15107/rcub_fiver_2440 .