TY  - JOUR
AU  - Mrđanović, Jasminka
AU  - Bogdanović, Višnja
AU  - Kiprovski, Biljana
AU  - Malenčić, Ðorđe
AU  - Mikulić-Petkovšek, Maja
AU  - Milovanović, Ivan
AU  - Mišan, Aleksandra
PY  - 2019
UR  - http://fiver.ifvcns.rs/handle/123456789/1860
AB  - The aim of this study was to characterize volatile and non-volatile compounds of rosemary from the North Adriatic region and to determine its antiproliferative activity, alone or in combination with radiomimetic bleomycin (BLM) on three malignant and one non-transformed human cell lines. Chemi-cal analysis of the volatile compounds revealed the presence of monoterpenes (93.8%), among which 1.8-cineol (32.9%) and camphor (15.5%) were the dominant compounds. Also, obtained results showed that the major polyphenolic constituents in rosemary extract were phenolic acids (rosmarinic acid and its derivatives up to 69.2 mg 100 g -1), as well as flavones and flavonols in the following order: lute-olin>isorhamnetin>quercetin>kaempferol>apigenin. Cell growth tests showed that rosemary extract alone exerted moderate antiproliferative activity, as well as a synergistic antiproliferative effect with bleomycin (EC 50 344.3-461.5 µg mL -1 and 58.6-292 µg mL -1 , respectively). The anti-tumor effect of rosemary extract in combination with BLM was much stronger, compared to BLM itself on the breast cancer cells. Through its proposed sensitizing effect, rosemary extract, in combination with the standard chemotherapeutics, could be used for the investigations of possible therapeutic modalities.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment
EP  - 51
IS  - 39
SP  - 44
DO  - 10.5937/leksir1939044M
ER  - 

@article{
author = "Mrđanović, Jasminka and Bogdanović, Višnja and Kiprovski, Biljana and Malenčić, Ðorđe and Mikulić-Petkovšek, Maja and Milovanović, Ivan and Mišan, Aleksandra",
year = "2019",
abstract = "The aim of this study was to characterize volatile and non-volatile compounds of rosemary from the North Adriatic region and to determine its antiproliferative activity, alone or in combination with radiomimetic bleomycin (BLM) on three malignant and one non-transformed human cell lines. Chemi-cal analysis of the volatile compounds revealed the presence of monoterpenes (93.8%), among which 1.8-cineol (32.9%) and camphor (15.5%) were the dominant compounds. Also, obtained results showed that the major polyphenolic constituents in rosemary extract were phenolic acids (rosmarinic acid and its derivatives up to 69.2 mg 100 g -1), as well as flavones and flavonols in the following order: lute-olin>isorhamnetin>quercetin>kaempferol>apigenin. Cell growth tests showed that rosemary extract alone exerted moderate antiproliferative activity, as well as a synergistic antiproliferative effect with bleomycin (EC 50 344.3-461.5 µg mL -1 and 58.6-292 µg mL -1 , respectively). The anti-tumor effect of rosemary extract in combination with BLM was much stronger, compared to BLM itself on the breast cancer cells. Through its proposed sensitizing effect, rosemary extract, in combination with the standard chemotherapeutics, could be used for the investigations of possible therapeutic modalities.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment",
pages = "51-44",
number = "39",
doi = "10.5937/leksir1939044M"
}

Mrđanović, J., Bogdanović, V., Kiprovski, B., Malenčić, Ð., Mikulić-Petkovšek, M., Milovanović, I.,& Mišan, A.. (2019). Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(39), 44-51.
https://doi.org/10.5937/leksir1939044M

Mrđanović J, Bogdanović V, Kiprovski B, Malenčić Ð, Mikulić-Petkovšek M, Milovanović I, Mišan A. Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment. in Lekovite sirovine. 2019;(39):44-51.
doi:10.5937/leksir1939044M .

Mrđanović, Jasminka, Bogdanović, Višnja, Kiprovski, Biljana, Malenčić, Ðorđe, Mikulić-Petkovšek, Maja, Milovanović, Ivan, Mišan, Aleksandra, "Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment" in Lekovite sirovine, no. 39 (2019):44-51,
https://doi.org/10.5937/leksir1939044M . .